Unit 4: Chapters 11-15
Unit 4 Assignments
Webquests (and Notes):
1. Cell Communication (Part 1)- hyperlinks are included. Complete the sheet as you go through the interactive websites. (*A hard copy will be provided for writing your answers). There is also a Part 2 for this WQ on another doc. I'm still in the process of deciding whether to do this now or wait until a later unit.
2. Cell Communication Notes
3. ATP vs GTP...make sure you read this.
4. Apoptosis Video (& 4 questions)
5. 2019- Since we are running a couple of days behind, we will likely only do parts of the Cell Cycle WQ- Mitosis and Meiosis: hyperlinks to websites are included. Here are the sheets you must complete while doing the interactives:
1. Quorum Sensing- Watch the Bonnie Bassler video on TED talks (~20 min) and answer these questions.
2- BOZEMAN: A) Signal Transduction- Bozeman Video- here's the video guide; B) Cell Communication Video- do this video guide
3- Diabetes and Insulin Signaling- Case Study
4- Mitosis/Meiosis- Bozeman Video - Do this WS
5- AP Biology Genetics Practice Problems #1- 2018 (includes mono & dihybrid, inc & codominance, mul alleles, sex-linked, epistasis)
6- Human Pedigrees WS.
8- Chromosomal Inheritance- Bozeman. Take notes in notebook.
9-Advanced Genetics- Bozeman Video. Watch this and complete the sheet.
10-Genetics Problems: Epistasis
11- Linkage and Recombination Freq
12-Gene Mapping (see the right column for recommended websites & videos)
13- Chi square- Bozeman Video
14- Chi square assignments - 2018. Refer to #1 and #2 in right column (under 'Genetics-Chi square") for a step by step example of how to solve a genetics problem.
15-Chi Square Practice Problems
16-Chi square LabBench. This is a PRE-LAB! Make sure you take notes in your lab notebook and take the quiz at the end. You MUST KNOW how to do this to do your upcoming lab. I WILL CHECK THIS BEFORE YOU START THE LAB!
17- Linkage Interactive: https://mathbench.umd.edu/modules/prob-stat_recombination/page03.htm
Answer Key(s)- I will either post these for a few days (and then remove the links) or give hard copies:
1- Linkage and Recombination Frequency
2- Create a Chromosome Map
Optional Reading Guides:
Jon Darkow Information Processing Simulation
*This will likely be done in the Plant and Animal Physiology unit
LABS & PRELABS:
1- Chi square- M&M We will make time to do this one before the actual lab. You get to eat your data 😁
2- Mitosis Lab- Chi square (not done 2019)
3- Chi square LabBench (Pre-lab)- 'Genetics of Organisms'.
4- Drosophila Virtual Fly Lab- This is the actual lab. The Pre-Lab, #3 above, must be completed before lab starts.
Other Virtual Labs:
Additional Practice Problems (not required in 2018, but GOOD PRACTICE):
1-Genetics Practice - Basic Mendelian Genetics - may just start with #6
2-Genetics Problems #1: Mendelian 'Basic Genetics- Monohybrids & Dihybrids'. Refer to Ch 14 PPt (and book) for how to do a "test (back) cross".
3-Genetics Problems #2: Advanced (Beyond Mendel)
4- Genetics Problems #3: Sex Linked
5-Genetics Problems #4: Mul Alleles (Chickens)
Possible Labs :
Mitosis and Cancer (*not done 2017 due to Hurricane Irma). Instead we did HHMI Biointeractive- (click & learn)
Meiosis Lab- will also need to cut these out for this Meiosis lab (*not done 2017-See "Virtual Labs" for what we did)
Chi square- Coins: Probably don't have time to do in 2017 (out 2 days because of weather)
Refer to this site
Corn Genetics PPt
Lab Handout (doesn't include X2)
Unit 4 Review
Keys will only be posted briefly
1- Mitosis and Meiosis review
2- Cell Communication Review Questions
3- Genetics Problems Review with Answers
4- More Genetics Review (with answers)
5- Be sure to review the Cell Cycle (and cancer). Remember I made this: Cell Cycle Control in a Nutshell
6- Go over linkage, recombination frequencies and gene mapping
7- Other selected Worksheet Keys:
Genetics Problems #1: Basic Genetics
Genetics Problems #2: Advanced (Beyond Mendel)
Genetics Problems #3: Sex Linked
Genetics Problems #4: Mul Alleles
Pedigrees- Pick up a hard copy from me (handwritten answers; I don't have a scanner)
Gene Mapping- see last page for key
Pedigrees- optional sheet
Epistasis- hard copy given in class
Chi square Practice Problems
Unit 4 PPts & Prezis
Videos, Lectures and Websites
Cell Communication- Ch 11
I recommend the video lectures on youtube by John Chapman. He is clear and moves at a good pace. However, there's one mistake in his G-protein video. GDP is not phosphorylated to GTP. Instead, GDP is replaced by GTP. Other than that, I think his videos are great. Also, I haven't had time to look, but if Biomonk has a video of this on youtube.com, I'm sure it's good.
*Speaking of GTP...make sure you read this.
2- G-protein receptors: https://www.youtube.com/watch?v=On8CGKDfXd8&t=2s
3- Tyrosine kinase: Links are in Ch 11 PPt
4- Ion gated channels: Links in Ch 11 PPt
There are many other good resources for better understanding signal transduction mechanisms: one is Garland Science, another is Kahn Academy. I also posted links to some good (and shorter) youtube videos in the Ch 11 PPt.
Apoptosis (vs Necrosis): short video (under 2 minutes!)- www.youtube.com/watch?v=7WRkY8q_F3k
Cell Cycle Control (checkpoints and cancer):
1- Good youtube video for understanding the Cell Cycle checkpoints and Cancer
2- Cyclins and Cdk: www.youtube.com/watch?v=WRH7xG7q6Sg
3- p53 gene: https://www.youtube.com/watch?v=9FJq2U8pDdA
4- Cell Cycle Control in a Nutshell- synopsis that explains the process (in my own words, for whatever that's worth!)
Genetics- Chi square:
1-chi_square_introduction_use.docx Chi square- Introduction (with example)
2- Chi square practice problem (here's the answer)
3- Excellent (crystal clear!) video of applying Chi square to a genetics problem.
4- Chi square (detailed explanation & step by step example)
5- Chi square test and its uses in biology
Linked Genes and Gene Mapping:
***Great video on linkage and mapping (6 min): https://www.youtube.com/watch?v=rzF6nG4C0nc
1- Read this from the Learn Genetics Utah site before starting problems regarding gene linkage. Take notes, if needed. Next, read this on sex linkage: learn.genetics.utah.edu/content/pigeons/sexlinkage/ Take notes. While you're on this site, read (and be able to explain) how telomeric DNA affects aging and cancer- click here.
2- Good video explaining linkage and recombination frequencies (his voice is rather monotone, but he's quite clear in his explanation): https://www.youtube.com/watch?v=iH8b-5BxtuY
3- Bozeman: Linked Genes-Watch this before doing #4 (below). www.youtube.com/watch?v=-_UcDhzjOio. (*Here's another really good video explaining linkage & recombination frequencies: www.youtube.com/watch?v=rzF6nG4C0nc)
4-Genetic Recombination and Gene Mapping (*I highly recommend this Bozeman video, if you are having trouble with Ch 15)
5- Good 'lecture' video of linkage and recombination frequencies (he works problems step-by-step on the white board)